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Mercury in Hair Is Inversely Related to Disease Associated Damage in Systemic Lupus Erythematosus.

Crowe, William, Doherty, Leanne, Watson, Gene, Armstrong, David, Ball, Elisabeth, Magee, Pamela, Allsopp, Philip, Bell, Aubrey, Strain, J J and McSorley, Emeir (2015) Mercury in Hair Is Inversely Related to Disease Associated Damage in Systemic Lupus Erythematosus. International journal of environmental research and public health, 13 (1). [Journal article]

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DOI: 10.3390/ijerph13010075

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, and environmental factors are proposed to exacerbate existing symptoms. One such environmental factor is mercury. The aim of this study was to investigate the relationship between exposure to mercury (Hg) and disease activity and disease associated damage in Total Hg concentrations in hair and urine were measured in 52 SLE patients. Dental amalgams were quantified. Disease activity was assessed using three indexes including the British Isles Lupus Assessment Group Index (BILAG). Disease associated damage was measured using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology SLICC/ACR Damage Index. Pearson's correlation identified a significant negative correlation between hair Hg and BILAG (r = -0.323, p = 0.029) and SLICC/ACR (r = -0.377, p = 0.038). Multiple regression analysis identified hair Hg as a significant predictor of disease associated damage as determined by SLICC/ACR (β = -0.366, 95% confidence interval (CI): -1.769, -0.155 p = 0.019). Urinary Hg was not related to disease activity or damage. Fish consumption is the primary route of MeHg exposure in humans and the inverse association of hair Hg with disease activity observed here might be explained by the anti-inflammatory effects of n-3 long chain polyunsaturated fatty acids also found in fish.

Item Type:Journal article
Keywords:mercury; lupus; disease activity
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Nursing
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Institute of Nursing and Health Research
Biomedical Sciences Research Institute
Institute of Nursing and Health Research > Managing Chronic Illness Research Centre
ID Code:33768
Deposited By: Dr Emeir McSorley
Deposited On:05 Apr 2016 10:20
Last Modified:30 Jul 2018 10:53

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