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Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Fowley, Colin, McHale, AP, McCaughan, Bridgeen, Fraix, A., Sortino, S. and Callan, J (2015) Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors. Chemical Communications, 51 (1). pp. 81-84. [Journal article]

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URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84915819826&partnerID=40&md5=e864a2a913e232bb3bfbce0149d1a38e

DOI: 10.1039/c4cc07827f


We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light. This journal is © The Royal Society of Chemistry.

Item Type:Journal article
Keywords:antineoplastic agent; biomaterial; carbon; carbon quantum dot nitric oxide photoreleaser nanohybrid conjugate; carboxylic acid; nitric oxide; quantum dot; unclassified drug; carbon; nanomaterial; nitric oxide; quantum dot, animal experiment; animal model; Article; cancer cell; controlled study; energy transfer; excitation; fluorescence microscopy; in vitro study; mouse; nonhuman; pancreas tumor; photochemotherapy; photon therapy; tumor volume; two photon phototherapy; xenograft; animal; Bagg albino mouse; cell survival; chemistry; drug effects; HeLa cell line; human; light; nanomedicine; Pancreatic Neoplasms; photon; phototherapy; SCID mouse; tumor cell line, Animals; Carbon; Cell Line, Tumor; Cell Survival; HeLa Cells; Humans; Light; Mice; Mice, Inbred BALB C; Mice, SCID; Nanomedicine; Nanostructures; Nitric Oxide; Pancreatic Neoplasms; Photons; Phototherapy; Quantum Dots; Transplantation, Heterologous
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:34133
Deposited By: Dr Bridgeen Callan
Deposited On:06 Apr 2016 13:42
Last Modified:06 Apr 2016 13:42

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