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A ratiometric fluorescent hydrogel sensor for zinc(II) based on a two fluorophore approach

Hamilton, Graham, Fullerton, L., McCaughan, Bridgeen, Donnelly, R.F. and Callan, J (2014) A ratiometric fluorescent hydrogel sensor for zinc(II) based on a two fluorophore approach. New Journal of Chemistry, 38 (7). pp. 2823-2830. [Journal article]

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URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902668922&partnerID=40&md5=3a25862c73cbd16260233d6f0a5f1228

DOI: 10.1039/c4nj00291a

Abstract

A polymeric ratiometric fluorescent sensor for Zn(II) has been developed based on a Zn(II) responsive naphthalimide fluorophore (λEM 535 nm) and a Zn(II) insensitive rhodamine calibration fluorophore (λEM 579 nm) both coupled to a common poly(allyl amine) backbone. A concentration dependent increase in the ratiometric response (I 535 nm/I579 nm) was observed in the 0-25 mM Zn(II) ion range for the sensor in aqueous buffer. The effect of dilution on the ratiometric intensity of the polymeric sensor was also studied and no change in ratiometric response was observed upon dilution to 50 of its original concentration. In contrast, when the polymeric sensor was incorporated within a Gantrez AN-139 hydrogel matrix, a linear ratiometric response was observed upon addition of increasing amounts of Zn(II) to the gel. Therefore, this approach offers the opportunity to determine Zn(II) concentration in environments where sensor concentration may vary dramatically. © the Partner Organisations 2014.

Item Type:Journal article
Keywords:allylamine derivative; naphthalimide derivative; poly(allylamine); rhodamine; unclassified drug; zinc, article; dilution; fluorescence; hydrogel; priority journal; sensor
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:34137
Deposited By: Dr Bridgeen Callan
Deposited On:06 Apr 2016 13:42
Last Modified:06 Apr 2016 13:42

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