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Concordance between common dry eye diagnostic tests

Graham, J. E., Moore, Johnny, Goodall, E. A., Dartt, D. A., Leccisotti, A., McGilligan, V. E. and Moore, Tara (2009) Concordance between common dry eye diagnostic tests. BRITISH JOURNAL OF OPHTHALMOLOGY, 93 (1). pp. 66-72. [Journal article]

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DOI: 10.1136/bjo.2007.131722


Aim: Large variations in results of diagnostic tests for mild to moderate dry eye are widely recognised. The purpose of this study was to assess if there was concordance between common dry eye diagnostic tests. Methods: A total of 91 subjects were recruited to the study. The tear film and ocular surface were evaluated using the phenol red thread test (PRT), tear film break-up time (TBUT), biomicroscopic examination and impression cytological assessment of conjunctival goblet cells. Dry eye symptoms were assessed using McMonnies' dry eye questionnaire (MQ) and statistical correlations between all tests were assessed. Results: This study cohort did not include severe aqueous deficient dry eye patients as determined by the PRT. A statistically significant difference was noted between PRT results and all other tests (p <= 0.001). Only Meibomian gland pathology, MQ, reduced goblet cell density and TBUT (<= 7 s) demonstrated correlation determined by McNemar's test. Conclusion: A correlation was found only between tests assessing lipid/mucous deficiency (Meibomian gland evaluation, goblet cell density, TBUT and MQ).

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Genomic Medicine
Biomedical Sciences Research Institute > Stratified Medicine
ID Code:3468
Deposited By: Professor Tara Moore
Deposited On:18 Dec 2009 14:44
Last Modified:16 May 2017 10:09

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