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Modulation of ROS production in photodynamictherapy using a pH controlled photoinducedelectron transfer (PET) based sensitiser

Atchison, J, Kamila, Sukanta, McEwan, C, Nesbitt, Heather, Davis, J, Fowley, Colin, Callan, Bridgeen, McHale, AP and Callan, John (2015) Modulation of ROS production in photodynamictherapy using a pH controlled photoinducedelectron transfer (PET) based sensitiser. Chemical Communications, 15 . pp. 16832-16835. [Journal article]

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URL: http://www.rsc.org/

DOI: 10.1039/c5cc07022h

Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours

Item Type:Journal article
Keywords:PDT, ROS, sensitiser, pH-controlled
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Computing & Engineering > School of Engineering
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Genomic Medicine
Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:34726
Deposited By: Professor Anthony McHale
Deposited On:08 Jun 2016 09:09
Last Modified:17 Oct 2017 16:23

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