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Lactonic Sophorolipids Increase Tumor Burden in Apcmin+/- Mice

MITCHELL, CA, Marchant, R, Banat, Ibrahim, Lydon, Helen and Callaghan, Breedge (2016) Lactonic Sophorolipids Increase Tumor Burden in Apcmin+/- Mice. PLoS One, 11 . [Journal article]

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URL: http://dx.doi.org/10.1371/journal.pone.0156845

DOI: 10.1371/journal.pone.0156845

Abstract

Sophorolipids (SL) are amphiphilic biosurfactant molecules consisting of a disaccharidesophorose with one fatty acid at the C1 position and optional acetylation at the C6’and C6”positions. They exist in a closed ring lactonic (LSL) or open acidic (ASL) structure Sophorolipidsare produced in crude mixtures in economically viable amounts by the yeast Starmerellabombicola and used in a variety of consumer products. Varying levels of antiproliferativeand anti-cancer activity of crude sophorolipid mixtures are described in a number of tumor cell lines in vitro. However, significant inter-study variation exists in the composition of sophorolipid species as well as other biologically active compounds in these mixtures, which makes interpretation of in vitro and in vivo studies difficult.We produced a 96% pure C18:1 lactonic sophorolipid that dose-dependently reduces the viability of colorectal cancer, as well as normal human colonic and lung cell lines in vitro. Oral administration of vehicle-only; or lactonic sophorolipids (50 mg/kg for 70 days), toApcmin+/- mice resulted in an increase in the number (55.5 ± 3.3 vs 70.50 ± 7.8: p < 0.05)and size (modal size 2mm vs 4mm) of intestinal polyps. Lactonic administration resulted in a systematic effect via reduced hematocrit (49.5 ± 1.0 vs 28.2 ± 2.0 vs: p<0.03) and splenomegaly (0.56 ± 0.03g vs 0.71 ± 0.04g; p<0.01) confirming exacerbation of disease progression in this model.

Item Type:Journal article
Keywords:Sophorolipids, Acidic, Colorectal cancer, Apcmin+/-, Caco-2 cells, HT29 cells, apoptosis, spleen, cancer treatment, mouse models, gastrointestinal tract
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:34990
Deposited By: Professor Christopher Mitchell
Deposited On:11 Jul 2016 09:12
Last Modified:25 Jan 2017 13:03

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