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Intracardiac impedance response during acute AF internal cardioversion using novel rectilinear and capacitor-discharge waveforms.

Rababah, AS, Walsh, SJ, Manoharan, G, Walsh, PR and Escalona, OJ (2016) Intracardiac impedance response during acute AF internal cardioversion using novel rectilinear and capacitor-discharge waveforms. Physiological Measurement, 37 (7). pp. 1129-1145. [Journal article]

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URL: http://iopscience.iop.org/issue/0967-3334/37/7

DOI: 10.1088/0967-3334/37/7/1129

Abstract

Intracardiac impedance (ICI) is a major determinant of success during internal cardioversion of atrial fibrillation (AF). However, there have been few studies that have examined the dynamic behaviour of atrial impedance during internal cardioversion in relation to clinical outcome. In this study, voltage and current waveforms captured during internal cardioversion of acute AF in ovine models using novel radiofrequency (RF) generated low-tilt rectilinear and conventional capacitor-discharge based shock waveforms were retrospectively analysed using a digital signal processing algorithm to investigate the dynamic behaviour of atrial impedance during cardioversion. The algorithm was specifically designed to facilitate the simultaneous analysis of multiple impedance parameters, including: mean intracardiac impedance (Z M), intracardiac impedance variance (ICIV) and impedance amplitude spectrum area (IAMSA) for each cardioversion event. A significant reduction in ICI was observed when comparing two successive shocks of increasing energy where cardioversion outcome was successful. In addition, ICIV and IAMSA variables were found to inversely correlate to the magnitude of energy delivered; with a stronger correlation found to the former parameter. In conclusion, ICIV and IAMSA have been evidenced as two key dynamic intracardiac impedance variables that may prove useful in better understanding of the cardioversion process and that could potentially act as prognostic markers with respect to clinical outcome.

Item Type:Journal article
Keywords:Atrial fibrillation, AF, acute AF model, internal cardioversion, intracardiac impedance variance, ICIV, impedance amplitude spectrum area, IAMSA, defibrillation.
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:35002
Deposited By: Professor Omar Escalona
Deposited On:03 Aug 2016 15:29
Last Modified:17 Oct 2017 16:24

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