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Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

Dixon, D (2015) Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics. Nanomedicine, 10 (8). pp. 1316-1326. [Journal article]

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URL: http://www.futuremedicine.com/doi/full/10.2217/nnm.14.219

DOI: 10.2217/nnm.14.219

Abstract

With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.

Item Type:Journal article
Keywords:nanomedicine, gold nanoparticles
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:35013
Deposited By: Dr Dorian Dixon
Deposited On:19 Aug 2016 14:32
Last Modified:17 Oct 2017 16:24

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