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Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker

Dixon, D and Harrison, E (2016) Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine, 11 (7). pp. 851-865. [Journal article]

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URL: http://www.futuremedicine.com/doi/abs/10.2217/nnm.16.28

DOI: 10.2217/nnm.16.28

Abstract

To create a clinically relevant gold nanoparticle (AuNP) treatment, the surface must be functionalized with multiple ligands such as drugs, antifouling agents and targeting moieties. However, attaching several ligands of differing chemistries and lengths, while ensuring they all retain their biological functionality remains a challenge. This review compares the two most widely employed methods of surface co-functionalization, namely mixed monolayers and hetero-bifunctional linkers. While there are numerous in vitro studies successfully utilizing both surface arrangements, there is little consensus regarding their relative merits. Animal and preclinical studies have demonstrated the effectiveness of mixed monolayer functionalization and while some promising in vitro results have been reported for PEG linker capped AuNPs, any potential benefits of the approach are not yet fully understood.

Item Type:Journal article
Keywords:Nanomedicine, gold nanoparticles
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:35014
Deposited By: Dr Dorian Dixon
Deposited On:19 Aug 2016 14:33
Last Modified:12 Jun 2017 11:29

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