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The potential use of rabies virus glycoproteinderived peptides to facilitate drug delivery into the central nervous system: a mini review

Huey, Rachel and Hawthorne, Susan (2016) The potential use of rabies virus glycoproteinderived peptides to facilitate drug delivery into the central nervous system: a mini review. Journal of Drug Targeting, . . pp. 1-7. [Journal article]

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URL: http://dx.doi.org/10.1080/1061186X.2016.1223676

DOI: 10.1080/1061186X.2016.1223676

Abstract

Rabies virus glycoprotein (RVG), a 505 amino acid type-1 glycoprotein, is responsible for the neurotrophic nature of the rabies virus infection. Despite varying reports in the literature as to which receptor is ultimately responsible for interaction of RVG with the nervous system, there is a strong argument for major nicotinic acetylcholine receptor (nAChR) involvement. Peptide derivatives of RVG, such as rabies virus-derived peptide (RDP) and RVG-29 are emerging as promising targeting ligands for the delivery of therapeutics to the central nervous system (CNS). The neurotrophic nature of RVG and indeed its derivatives may be due to interaction with ubiquitous nAChRs principally, but also association with other neural cell-specific molecules such as neural cell adhesion molecule (NCAM). It is possible that nAChR-mediated uptake of RVG-derived peptides may serve as an attractive new approach for targeting drug delivery to the brain. Potential application of this type of drug delivery system extends to many diseases affecting the CNS, where specific and effective drug delivery is normally a challenging process

Item Type:Journal article
Keywords:rabies virus; nicotinic acetylcholine receptor; peptide; targeted; delivery; cental nervous system
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:35693
Deposited By: Dr Susan Hawthorne
Deposited On:07 Oct 2016 10:40
Last Modified:17 Oct 2017 16:25

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