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Oral spray wintertime vitamin D3 supplementation has no impact on inflammation in Gaelic footballers

Todd, Joshua, McSorley, Emeir M, Pourshahidi, L. Kirsty, Madigan, Sharon, Crowe, William, Laird, Eamon, Healy, Martin, McNeilly, Andrea and Magee, Pamela (2016) Oral spray wintertime vitamin D3 supplementation has no impact on inflammation in Gaelic footballers. Scandinavian Journal of Medicine & Science in Sports, n/a . [Journal article]

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DOI: 10.1111/sms.12785

Abstract

Vitamin D inadequacy [total 25(OH)D <50nmol/L] is widespread in athletes. The biologicallyactive metabolite, 1,25-dihydroxyvitamin D, may be involved in regulating inflammation althoughin vitro findings have not been consistently replicated in human intervention trials. This study,conducted at a latitude of 55ºN, aimed to assess inflammatory biomarkers in Gaelic footballersbefore and after a wintertime vitamin D3 intervention. Samples from a 12-week double-blind,randomised, placebo-controlled trial, in which 42 Gaelic footballers received 3000IU (75Hg)vitamin D3 daily or placebo via oral spray solutions, were analysed for a range of inflammatorybiomarkers. Cytokines (interleukin-8 and tumour necrosis factor-α), cathelicidin and highsensitivity C-reactive protein were quantified by multiplex assay, ELISA and clinical biochemistryrespectively. White blood cell, lymphocyte and neutrophil concentrations were determined by full blood profile. Data on total 25-hydroxyvitamin D, measured by LC-MS/MS, were available fromthe previous study. Vitamin D3 supplementation significantly increased mean total 25-hydroxyvitamin D concentrations from 47 to 84nmol/L (P=0.006); yet this had no effect on whiteblood cell count (P=0.699), lymphocyte (P=0.694), neutrophil (P=0.594), interleukin-8(P=0.334), tumour necrosis factor-α (P=0.587), cathelicidin (P=0.745) or high sensitivity Creactive protein concentration (P=0.621) compared to placebo. 12-weeks vitamin D3supplementation did not impact the immune profile of Gaelic footballers. This is likely becausebiomarkers were within their respective normal range or at a concentration similar to that of thegeneral population at baseline. Future studies are encouraged to use inflammation as theirprimary outcome measure and recruit athletes at risk of compromised immunity.

Item Type:Journal article
Keywords:vitamin D, oral spray, inflammation, athletes, supplementation
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Sport
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
Sport and Exercise Sciences Research Institute
Sport and Exercise Sciences Research Institute > Centre for Physical Activity and Health
ID Code:35860
Deposited By: Dr Pamela Magee
Deposited On:13 Sep 2016 09:11
Last Modified:17 Oct 2017 16:25

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