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Boron supplementation and activated factor VII in healthy men

Wallace, JMW, Hannon-Fletcher, MPA, Robson, PJ, Gilmore, WS, Hubbard, SA and Strain, JJ (2002) Boron supplementation and activated factor VII in healthy men. European Journal of Clinical Nutrition, 56 (11). pp. 1102-1107. [Journal article]

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Objective: The aim of the present study was to determine whether postprandial concentrations of the active component of serine protease coagulation factor VII (Vila) were lowered by acute boron supplementation in vivo. Design: An acute, randomized, placebo-controlled, double blind, cross-over study. Setting: Free-living population. Subjects: Fifteen apparently healthy men, aged 45-65y. Interventions: Subjects visited the Centre on two occasions, with the study days separated by a minimum of 2 weeks. Following collection of a fasting blood sample, subjects received either placebo or acute bolus of 11.6mg boron (given as 102.6mg sodium tetraborate decahydrate) together with a standard fat-rich meal. Blood samples were obtained at 1, 2, 4 and 6 h after the administration of the test meal, during which time subjects were at liberty to consume deionized water only. Blood samples were assayed for concentrations of insulin, glucose, lipids and boron. Measurement of the concentration of activated factor Vila and of factor VII antigen, and of the activity of coagulation factors VII, IX and X was also carried out. Results: Plasma boron concentrations were significantly higher following consumption of the boron supplement compared with placebo (0.124+/-0.02 vs 0.008+/-0.01 mg/l; Pless than or equal to0.001). There was no significant effect of acute boron supplementation on plasma insulin and glucose concentration or on blood lipid or coagulation factor profile. Factor Vila rose significantly following consumption of the high fat meal (1.05+/-0.07 vs 1.26+/-0.07; Pless than or equal to0.001), but this increase was not altered by boron supplementation. Conclusions: Results from this study suggest that acute boron supplementation (at 11.6 mg boron) does not alter the activity of factor Vila following consumption of a high-fat meal. Sponsorship: This work was funded by Borax Europe Ltd.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Institute of Nursing and Health Research
Biomedical Sciences Research Institute
ID Code:3588
Deposited By: Dr Julie Wallace
Deposited On:15 Dec 2009 15:34
Last Modified:11 Feb 2013 16:09

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