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Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells

Rojo, Luis, Gharibi, Borzo, McLister, Robert, Meenan, Brian and Deb, Sanjukta (2016) Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells. Scientific Reports, 6 (30548). [Journal article]

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URL: http://www.nature.com/articles/srep30548

DOI: 10.1038/srep30548

Abstract

Phosphonates have emerged as an alternative for functionalization of titanium surfaces by theformation of homogeneous self-assembled monolayers (SAMs) via Ti-O-P linkages. This study presents results from an investigation of the modification of Ti6Al4V alloy by chemisorption of osseoinductive alendronate using a simple, effective and clean methodology. The modified surfaces showed a tailored topography and surface chemistry as determined by SEM microscopy and RAMAN spectroscopy. X-ray photoelectron spectroscopy revealed that an effective mode of bonding is created between the metal oxide surface and the phosphate residue of alendronate, leading to formation of homogenous drug distribution along the surface. In-vitro studies showed that alendronate SAMs induce differentiation of hMSC to a bone cell phenotype and promote bone formation on modified surfaces. Here we show that this novel method for the preparation of functional coatings on titanium-based medical devices provides osseoinductive bioactive molecules to promote enhanced integration at the site of implantation.

Item Type:Journal article
Keywords:Phosphonates, titanium surfaces, self-assembled monolayers (SAMs), alendronate, hMSC, bone formation.
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:35953
Deposited By: Professor Brian Meenan
Deposited On:21 Oct 2016 12:11
Last Modified:21 Oct 2016 12:11

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