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The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial

Norton, Maria C., Clark, Christine J., Tschanz, JoAnn T., Hartin, Phillip, Fauth, Elizabeth B., Gast, Julie A., Dorsch, Travis E., Wengreen, Heidi, Nugent, Chris, Robinson, W. David, Lefevre, Michael, McClean, S, Cleland, I., Schaefer, Sydney Y. and Aguilar, Sheryl (2015) The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 1 (1). pp. 53-62. [Journal article]

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URL: http://dx.doi.org/10.1016/j.trci.2015.05.001

DOI: doi:10.1016/j.trci.2015.05.001

Abstract

ntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.

Item Type:Journal article
Keywords:Lifestyle behavioral intervention, Randomized controlled trial, Middle age, Multidomain, Technology
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Computing and Information Engineering
Faculty of Computing & Engineering > School of Computing and Mathematics
Research Institutes and Groups:Computer Science Research Institute > Smart Environments
Computer Science Research Institute
Computer Science Research Institute > Information and Communication Engineering
ID Code:36069
Deposited By: Professor Christopher Nugent
Deposited On:07 Oct 2016 11:07
Last Modified:07 Oct 2016 11:07

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