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Surface-Adsorbed Long G-Quadruplex Nanowires Formed by G:C Linkages

Troha, Tinkara, Drevenšek-Olenik, Irena, Webba da Silva, Mateus and Spindler, Lea (2016) Surface-Adsorbed Long G-Quadruplex Nanowires Formed by G:C Linkages. Langmuir, 32 (28). pp. 7056-7063. [Journal article]

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URL: http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.6b01222

DOI: 10.1021/acs.langmuir.6b01222

Abstract

G-quadruplexes connected into long, continuous nanostructures termed G-wires show properties superior to dsDNA when applied in nanotechnology. Using AFM imaging, we systematically studied surface adsorption of a set of G-rich oligonucleotides with GC-termini for their ability to form long G-wires through G:C pairing. We investigated the effects of increasing sequence length, the type of nucleotide in the side loops, and removal of the CG-3′ terminus. We found that sequences with adenine in the side loops most readily form G-wires. The role of magnesium as an efficient surface-anchoring ion was also confirmed. Conversely, as resolved from dynamic light scattering measurements, magnesium had no ability to promote G-quadruplex formation in solution. These insights may help in selecting prosperous candidates for construction of G-quadruplex based nanowires and to explore them for their electronic properties

Item Type:Journal article
Keywords:nanowire, quadruplex, G-wires, DNA nanotechnology
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:36130
Deposited By: Dr Mateus Webba da Silva
Deposited On:04 Nov 2016 14:38
Last Modified:17 Oct 2017 16:26

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