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An Integrated Modelling Framework for Neural Circuits with Multiple Neuromodulators

Joshi, Alok, Youssofzadeh, Vahab, Vemana, Vinith, McGinnity, TM, Prasad, Girijesh and Wong-Lin, KongFatt (2017) An Integrated Modelling Framework for Neural Circuits with Multiple Neuromodulators. Journal of The Royal Society Interface, 14 (126). [Journal article]

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URL: http://rsif.royalsocietypublishing.org/content/14/126/20160902

DOI: 10.1098/rsif.2016.0902

Abstract

Neuromodulators are endogenous neurochemicals that regulate biophysical and biochemical processes, which control brain function and behaviour, and are often the targets of neuropharmacological drugs. Neuromodulator effects are generally complex partly due to the involvement of broad innervation, co-release of neuromodulators, complex intra- and extra-synaptic mechanism, existence of multiple receptor subtypes, and high interconnectivity within the brain. In this work, we propose an efficient yet sufficiently realistic computational neural modelling framework to study some of these complex behaviours. Specifically, we propose a novel dynamical neural circuit model that integrates the effective neuromodulator-induced currents based on various experimental data (e.g. electrophysiology, neuropharmacology and voltammetry). The model can incorporate multiple interacting brain regions including neuromodulator sources, simulate efficiently, and easily extendable to large-scale brain models e.g. for neuroimaging purposes. As an example, we model a network of mutually interacting neural populations in the lateral hypothalamus, dorsal raphe nucleus and locus coeruleus, which are major sources of neuromodulator orexin/hypocretin, serotonin and norepinephrine/noradrenaline, respectively, and which play significant roles in regulating many physiological functions. We demonstrate that such model can provide predictions of systemic drug effects of the popular antidepressants (e.g. reuptake inhibitors), neuromodulator antagonists, or their combinations. Finally, we developed friendly graphical user interface software for model simulation and visualization for both fundamental sciences and pharmacological studies.

Item Type:Journal article
Keywords:Computational neural circuit models, neuromodulators, neuropharmacology, orexin/hypocretin, serotonin, norepinephrine/noradrenaline
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Computing and Intelligent Systems
Research Institutes and Groups:Computer Science Research Institute > Intelligent Systems Research Centre
Computer Science Research Institute
ID Code:36580
Deposited By: Dr Kongfatt Wong-Lin
Deposited On:23 Jan 2017 14:09
Last Modified:22 May 2017 11:08

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