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A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

Nomikou, N, Curtis, K, McEwan, C, O'Hagan, Barry, Callan, Bridgeen, Callan, J and McHale, AP (2017) A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy. Acta Biomaterialia, 49 . pp. 414-421. [Journal article]

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URL: https://www.journals.elsevier.com/acta-biomaterialia/

DOI: 10.1016/j.actbio.2016.11.031

Abstract

A PLGA-based multifunctional biodegradable nanoparticle platform co-harboring hematoporporphyrin and indocyanine green has been developed. In vitro studies demonstrate ultrasound and light stimulated generation of cytotoxic reactive oxygen species. In vivo studies demonstrate that the ICG component facilitates nIR fluorescence imaging that demonstrates accumulation of IV- administered nanoparticles in tumours. In vivo studies also demonstrate ultrasound- and light-mediated inhibition of tumor growth in animals treated with the platform. Since the platform consists entirely of clinically-approved agents it could find use in sonodynamic- and photodynamic-based therapies for cancer.

Item Type:Journal article
Keywords:nanoparticle, sonodynamic, photodynamic, cancer, real-time, imaging, therapy
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Genomic Medicine
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:36840
Deposited By: Professor Anthony McHale
Deposited On:08 Feb 2017 16:37
Last Modified:27 Feb 2017 12:30

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