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Development of a Cradle-to-Grave Approach for Acetylated Acidic Sophorolipid Biosurfactants

Mitchell, CA, Banat, Ibrahim and Marchant, R (2017) Development of a Cradle-to-Grave Approach for Acetylated Acidic Sophorolipid Biosurfactants. ACS Sustainable Chem. Eng., 5 (1). pp. 1186-1198. [Journal article]

[img] Text - Accepted Version

DOI: 10.1021/acssuschemeng.6b02570


Microbial production of biosurfactants represents one of the most interesting alternatives to classical petrol-based compounds due to their low toxicity, high biodegradability, and biological production processes from renewable bioresources. However, some of the main drawbacksgenerally encountered are the low productivities and the small number of chemical structures available, which limit widespread application of biosurfactants. Although chemical derivatization of (microbial) biosurfactants offers opportunities to broaden the panel of available molecules, direct microbial synthesis is still the preferred option and the use of engineered strains is becoming a valid alternative. In this multidisciplinary work we show the entire process of conception, upscaling of fermentation (150 L) and sustainable purification (filtration), application (foaming, solubilization, antibacterial), and life cycle analysis of acetylated acidic sophorolipids, directly produced by the Starmerella bombicola esterase knock out yeast strain, rather than purified using chromatography from the classical, but complex, mixture of acidic and lactonic sophorolipids.

Item Type:Journal article
Keywords:Starmerella bombicola, Glycolipids, Self-assembly, Life cycle analysis, Antimicrobial, Genetic engineering
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:37018
Deposited By: Professor Christopher Mitchell
Deposited On:06 Mar 2017 09:09
Last Modified:22 Dec 2017 23:23

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