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Understanding the role of Propionibacterium acnes in acne vulgaris: the critical importance of skin sampling methodologies

Omer, Hélène, McDowell, Andrew and Alexeyev, Oleg (2017) Understanding the role of Propionibacterium acnes in acne vulgaris: the critical importance of skin sampling methodologies. Clinics In Dermatology, 35 . pp. 118-129. [Journal article]

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DOI: 10.1016/j.clindermatol.2016.10.003

Abstract

Acne vulgaris is a chronic inflammatory skin condition, classified by the Global Burden of Disease Study as the eighth most prevalent disease worldwide. The pathophysiology of the condition has been extensively studied, with an increase in sebum production, abnormal keratinization of the pilosebaceous follicle, and an inflammatory immune response all implicated in its etiology. One of the most disputed points, however, is the role of the Gram-positive anaerobic bacterium Propionibacterium acnes in the development of acne, particularly when this organism is also found in normal sebaceous follicles of healthy skin. Against this background, we now describe the different sampling strategies that have been adopted for qualitative and quantitative study of P. acnes within intact hair follicles of the skin, and discuss the strengths and weaknesses of such methodologies for investigating the role of P. acnes in the development of acne.

Item Type:Journal article
Keywords:Skin, acne, Propionibacterium acnes, inflammation, skin swab, skin biopsy, gel biopsy, comedone extraction, phylogroups, biofilm
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Stratified Medicine
ID Code:37626
Deposited By: Dr Andrew McDowell
Deposited On:02 May 2017 08:42
Last Modified:10 Jul 2017 14:47

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