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Emblica officinalis stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro

Kasabri, V, Flatt, Peter and Abdel-Wahab, YHA (2014) Emblica officinalis stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro. European Journal of Medicinal Plants, 4 (6). pp. 753-770. [Journal article]

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DOI: 10.9734/EJMP/2014/8585

Abstract

Aim: Medicinal, edible and aromatic plants and natural products have been used worldwide for the management of diabetes mellitus. The aim of this study was to investigate the efficacy and mode of action of Emblica officinalis Gaertn. (Phyllanthaceae) used traditionally for treatment of diabetes. Study Design: Using multiple In vitro models; this study was designed to investigate the antidiabetes efficacy and mode of action of E. officinalis.Place and Duration of Study: School of Biomedical Sciences, University of Ulster, 2001-2004Results: E. officinalis aqueous extracts (AEs) stimulated basal insulin output and potentiated glucose-stimulated insulin secretion concentration-dependently in the clonal pancreatic beta cell line, BRIN-BD11 (p<0.001). The insulin secretory activity of plant extract was abolished in the absence of extracellular Ca2+ and by inhibitors of cellular Ca2+ uptake, diazoxide (p<0.001, n=8). Furthermore, the extract increased insulin secretion in depolarised cells and further augmented insulin secretion triggered by IBMX and tolbutamide. E. officinalis AE (1 mg/mL) displayed insulin mimetic activity (230%, p<0.001). Furthermore, it enhanced insulin-stimulated glucose transport in 3T3 L1 adipocytes by 460% (p<0.001). E. officinalis augmented also synergistically (p<0.001) insulin action, when co-incubated with insulin sensitizers; metformin (2.4-fold), vanadate (4.9-fold), tungstate (4.8-fold) and molybdate (6-fold). At higher concentrations (0.5-5 mg/mL), the extract also produced 8-74% (p<0.001) decrease in enzymatic starch digestion In vitro. E. officinalis AEs (1-50 mg/mL) inhibited protein glycation 44-87% (p<0.001). Conclusion: This study has revealed that water soluble bioactive principles in E. officinalis extract stimulate insulin secretion, enhance insulin action and inhibit both protein glycation and starch digestion. The former actions are dependent on the bioeffective component (s) in the plant being absorbed intact. Future work assessing the use of Emblica officinalis as adjunctive therapeutic nutraceutical or as a source of bioactive antidiabetic principles may provide new opportunities for the integrated management/prevention/reversal of diabetes

Item Type:Journal article
Keywords:Emblica officinalis Gaertn; (Phyllanthaceae); insulin secretion; insulin action; starch digestion; peptide glycation.
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:37996
Deposited By: Dr Nigel Irwin
Deposited On:01 Jun 2017 14:24
Last Modified:01 Jun 2017 14:24

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