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Mechanisms underlying antidiabetic effects of Ocimum sanctum leaf extracts in animal models of type 1 and type 2 diabetes

Hannan, JMA, Ojo, Opeolu, Ali, L, Rokeya, B, Khaleque, J, Akhter, M, Flatt, Peter and Abdel-Wahab, YHA (2014) Mechanisms underlying antidiabetic effects of Ocimum sanctum leaf extracts in animal models of type 1 and type 2 diabetes. European Journal of Medicinal Plants, 5 (1). pp. 1-12. [Journal article]

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DOI: 10.9734/EJMP/2015/11840

Abstract

Aim: This study investigated mechanisms by which O. sanctum leaf extracts ameliorate hyperglycaemia using animal and cellular models of diabetes. Place and Duration of Study: Diabetes Research Laboratory, University of Ulster, Coleraine, United Kingdom and Research Division, BIRDEM, Dhaka, Bangladesh; 8 months. Methodology: Acute anti-diabetic effects of ethanolic extracts of O. sanctum were examined in normal and chemically-induced type 1 and 2 diabetic rats. Effects of extracts on glucose absorption, intestinal disaccharidase activity and gastrointestinal motility in type 2 diabetic rats and on glucose uptake and insulin action in 3T3-L1 cells were assessed. Results: Treatment with the extract (1.25 g/kg bw) significantly improved oral glucose tolerance in normal and type 2 diabetic rats and suppressed blood glucose elevation after oral sucrose (2.5 g/kg bw) administration. The extract significantly reduced glucose absorption, gastrointestinal motility and disaccharidase activity. A 28-day treatment with O. sanctum decreased serum glucose, increased liver glycogen and enhanced circulating insulin and total oxidant status in type 2 diabetic rats. Glucose transport and insulin action in 3T3-L1 were increased by extract. Conclusion: O. sanctum represents a useful as a source for discovery of novel antidiabetic compounds and as a dietary adjunct for the management of type 2 diabetes and its complications

Item Type:Journal article
Keywords:Ocimum sanctum; 3T3 adipocytes; intestinal disaccharidase activity; hepatic glycogen; glucose uptake.
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:37998
Deposited By: Dr Nigel Irwin
Deposited On:01 Jun 2017 14:24
Last Modified:01 Jun 2017 14:24

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