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Aqueous Bark Extracts of Terminalia Arjuna Stimulates Insulin Release, Enhances Insulin Action and Inhibits Starch Digestion and Protein Glycation in Vitro

Thomson, HAJ, Ojo, Opeolu, Flatt, Peter and Abdel-Wahab, YHA (2014) Aqueous Bark Extracts of Terminalia Arjuna Stimulates Insulin Release, Enhances Insulin Action and Inhibits Starch Digestion and Protein Glycation in Vitro. Austin Journal of Endocrinology and Diabetes, 1 (1). p. 1001. [Journal article]

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URL: http://austinpublishinggroup.com/endocrinology-diabetes/fulltext/ajed-v1-id1001.php

Abstract

Scientific evidence for the effects of Terminalia arjuna on diabetes mellitus is lacking. This study investigated the anti-diabetic efficacy and mode of action of the bark extract of Terminalia arjuna. Insulin-release from BRIN-BD11 cells was assessed in the absence or presence of T. arjuna extracts and modulators of insulin-secretion. Insulin concentration and intracellular calcium ([Ca2+]i) were measured by radioimmunoassay and FLEXstationTM respectively. Adipocyte glucose-uptake with 3T3-L1 fibroblasts, starch digestion with α–amylase and protein glycation were assessed in vitro. Terminalia arjuna extract stimulated insulin-release alone (p<0.001), in combination with known modulators but not without extracellular Ca2+. It increased intracellular calcium but had no effects on depolarised cells. Glucose-uptake was enhanced in the presence of T. arjuna (P< 0.001). At higher concentrations, the extract decreased starch digestion and inhibited protein glycation (p<0.001). Terminalia arjuna extract possesses antidiabetic potential and may provide new opportunities for the treatment of diabetes.

Item Type:Journal article
Keywords:Terminalia arjuna; diabetes; insulin; glucose uptake
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:37999
Deposited By: Dr Nigel Irwin
Deposited On:01 Jun 2017 14:24
Last Modified:01 Jun 2017 14:24

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