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Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens.

Valotteau, Claire, Banat, Ibrahim, Mitchell, Christopher, Lydon, Helen, Marchant, Roger, Babonneau, Florence, Pradier, Claire-Marie, Baccile, Niki and Humblot, Vincent (2017) Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens. Colloids and Suirfaces B: Biointerfaces, online . [Journal article]

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DOI: http://dx.doi.org/doi:10.1016/j.colsurfb.2017.05.072

Abstract

Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties.We show that they can be used to develop biocidal monolayers against Listeria ivanovii, aGram-positive bacterium. The present work points out the dependence between thesurface density and the antibacterial activity of grafted sophorolipids. It also emphasizesthe broad spectrum of activity of these coatings, demonstrating their potential againstboth Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis,Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonasaeruginosa and Salmonella typhymurium). After exposure to sophorolipids grafted ontogold, all these bacterial strains show a significant reduction in viability resulting frommembrane damage as evidenced by fluorescent labelling and SEM-FEG analysis.

Item Type:Journal article
Keywords:Biosurfactant, sophorolipid, gold, antibacterial
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:38085
Deposited By: Professor Roger Marchant
Deposited On:07 Jun 2017 10:43
Last Modified:17 Oct 2017 16:30

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