Ulster University Logo

Magnetically Responsive Microbubbles as Delivery Vehicles for Targeted Sonodynamic and Antimetabolite Therapy of Pancreatic Cancer

Sheng, Yinjie, Beguin, Estelle, Nesbitt, Heather, Kamila, Sukanta, Owen, Joshua, Barnsley, Lester, Callan, Bridgeen, O'Kane, Christopher, Nomikou, Nikolitsa, Hamoudi, Rifat, Taylor, Mark A, Love, Mark, Kelly, Paul, O'Rourke, Declan, Stride, Eleanor, McHale, AP and Callan, J (2017) Magnetically Responsive Microbubbles as Delivery Vehicles for Targeted Sonodynamic and Antimetabolite Therapy of Pancreatic Cancer. Journal of Controlled Release, 262 . pp. 192-200. [Journal article]

[img] Text - Accepted Version
Indefinitely restricted to Repository staff only.

962kB
[img] Text (Confirmation of acceptance) - Other
Indefinitely restricted to Repository staff only.

878B

Abstract

Magnetically responsive microbubbles (MagMBs), consisting of an oxygen gas core and a phospholipid coating functionalised with Rose Bengal (RB) and/or 5-fluorouracil (5-FU), were assessed as a delivery vehicle for the targeted treatment of pancreatic cancer using combined antimetabolite and sonodynamic therapy (SDT). MagMBs delivering the combined 5-FU/SDT treatment produced a reduction in cell viability of over 50% when tested against a panel of four pancreatic cancer cell lines in vitro. Intravenous administration of the MagMBs to mice bearing orthotopic human xenograft BxPC-3 tumours yielded a 48.3% reduction in tumour volume relative to an untreated control group (p<0.05) when the tumour was exposed to both external magnetic and ultrasound fields during administration of the MagMBs. In contrast, application of an external ultrasound field alone resulted in a 27% reduction in tumour volume. In addition, activated caspase and BAX protein levels were both observed to be significantly elevated in tumours harvested from animals treated with the MagMBs in the presence of magnetic and ultrasonic fields when compared to expression of those proteins in tumours from either the control or ultrasound field only groups (p<0.05). These results suggest MagMBs have considerable potential as a platform to enable the targeted delivery of combined sonodynamic / antimetabolite therapy in pancreatic cancer.

Item Type:Journal article
Keywords:Microbubbles, magnetic targeting, drug delivery, hypoxia, 5-fluoruracil, Rose Bengal, sonodynamic therapy, antimetabolite therapy, pancreatic cancer.
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:38527
Deposited By: Professor John Callan
Deposited On:30 Aug 2017 15:11
Last Modified:17 Oct 2017 16:31

Repository Staff Only: item control page