Ulster University Logo

RD Lawrence Lecture 2017 Incretins: the intelligent hormones in diabetes.

Gault, Victor A (2017) RD Lawrence Lecture 2017 Incretins: the intelligent hormones in diabetes. Diabetic Medicine, N/A . [Journal article]

[img] Text - Accepted Version
544kB
[img] Text
Restricted to Repository staff only

13kB

DOI: 10.1111/dme.13522

Abstract

The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have attracted considerable scientific and clinical interest due largely to their insulin-releasing and glucose-lowering properties. Indeed, GLP-1-based therapies are now key treatment options for many people with diabetes worldwide. In contrast, GIP-based agents have yet to reach the clinic based primarily on the impaired insulinotropic action of GIP observed in people with diabetes. Nevertheless, GIP is a key physiological regulator of insulin secretion and stable forms of GIP show much promise in rodent models to alleviate diabetes-obesity. Recent studies suggest that GIP may have an important role to play in a combination therapeutic approach or bioengineered with other gut peptides. Moreover, recent experimental studies indicate that incretins also exert pleiotropic effects in regions of the brain associated with learning and memory, thereby supporting preclinical data demonstrating that incretin-based drugs improve cognitive function. This review article, based on the RD Lawrence Lecture presented at Diabetes UK Annual Professional Conference (2017), provides a brief overview of incretins with a major focus on GIP, the development of designer GIP analogues, and how these molecules can improve cognition. Thus, incretins can be considered as 'the intelligent hormones' and may hold the key to successfully treating the alarming rise in neurodegenerative disorders

Item Type:Journal article
Keywords:GIP, GLP-1, incretin, brain, cognition
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:38847
Deposited By: Dr Nigel Irwin
Deposited On:23 Oct 2017 08:21
Last Modified:16 Oct 2018 22:23

Repository Staff Only: item control page