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Maternal vitamin D status and the relationship with neonatal anthropometric and childhood neurodevelopmental outcomes: Results from the Seychelles Child Development Nutrition Study

Laird, Eamon, Thurston, Sally, van Wijngaarden, Edwin, Shamlaye, Conrad, Myers, Gary, Davidson, Philip, Watson, Gene, McSorley, E. M., Mulhern, Maria S., Yeates, Alison J., Ward, Mary, McNulty, Helene and Strain, JJ (2017) Maternal vitamin D status and the relationship with neonatal anthropometric and childhood neurodevelopmental outcomes: Results from the Seychelles Child Development Nutrition Study. Nutrients, 9 (11). pp. 1235-1247. [Journal article]

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DOI: 10.3390/nu9111235

Abstract

Vitamin D has an important role in early life; however, the optimal vitamin D statusduring pregnancy is currently unclear. There have been recent calls for pregnant women tomaintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yetlittle is known about the long-term potential benefits or safety of achieving such high maternal25(OH)D concentrations for infant or child health outcomes. We examined maternal vitaminD status and its associations with infant anthropometric and later childhood neurocognitiveoutcomes in a mother-child cohort in a sun-rich country near the equator (4.6◦ S). This study wasconducted in pregnant mothers originally recruited to the Seychelles Child Development NutritionStudy. Blood samples (n = 202) taken at delivery were analysed for serum 25-hydroxyvitaminD (25(OH)D) concentrations. Multiple linear regression models assessed associations betweenmaternal 25(OH)D and birth weight, infant head circumference, and neurocognitive outcomes inthe children at age 5 years. Mothers were, on average, 27 years of age, and the children’s averagegestational age was 39 weeks. None of the women reported any intake of vitamin D supplements.Maternal 25(OH)D concentrations had a mean of 101 (range 34–218 nmol/L) and none were deficient(<30 nmol/L). Maternal 25(OH)D concentrations were not associated with child anthropometric orneurodevelopmental outcomes. These findings appear to indicate that a higher vitamin D status isnot a limiting factor for neonatal growth or neurocognitive development in the first 5 years of life.Larger studies with greater variability in vitamin D status are needed to further explore optimalcut-offs or non-linear associations (including for maternal health) that might exist among populationswith sub-optimal exposure.

Item Type:Journal article
Keywords:vitamin D; pregnancy; birth; childhood; neurodevelopment; health
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:39039
Deposited By: Dr Alison Yeates
Deposited On:07 Dec 2017 15:07
Last Modified:07 Dec 2017 15:30

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