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Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug

Kastner, Elisabeth, Verma, Varun, Lowry, Deborah and Perrie, Yvonne (2015) Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug. International Journal of Pharmaceutics, 485 (1-2). pp. 122-130. [Journal article]

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URL: http://dx.doi.org/doi 10.1016/j.ijpharm.2015.02.063

DOI: doi 10.1016/j.ijpharm.2015.02.063

Abstract

Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs.

Item Type:Journal article
Keywords:Liposomes, Microfluidics, Poorly soluble drugs, Bilayer loading, High throughput
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:39114
Deposited By: Dr Deborah Lowry
Deposited On:02 Jan 2018 14:44
Last Modified:02 Jan 2018 14:44

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