Ulster University Logo

Indwelling catheters and medical implants with FXIIIa inhibitors: A novel approach to the treatment of catheter and medical device-related infections

Daneshpour, Nooshin, Collighan, Russell, Perrie, Yvonne, Lambert, Peter, Rathbone, Dan, Lowry, Deborah and Griffin, Martin (2013) Indwelling catheters and medical implants with FXIIIa inhibitors: A novel approach to the treatment of catheter and medical device-related infections. European Journal of Pharmaceutics and Biopharmaceutics, 83 (1). pp. 106-113. [Journal article]

Full text not available from this repository.

URL: http://dx.doi.org/doi 10.1016/j.ejpb.2012.09.005

DOI: doi 10.1016/j.ejpb.2012.09.005

Abstract

Central venous catheters (CVCs) are being utilized with increasing frequency in intensive care and general medical wards. In spite of the extensive experience gained in their application, CVCs are related to the long-term risks of catheter sheath formation, infection, and thrombosis (of the catheter or vessel itself) during catheterization. Such CVC-related-complications are associated with increased morbidity, mortality, duration of hospitalization, and medical care cost [1].The present study incorporates a novel group of Factor XIIIa (FXIIIa, plasma transglutaminase) inhibitors into a lubricious silicone elastomer in order to generate an optimized drug delivery system whereby a secondary sustained drug release profile occurs following an initial burst release for catheters and other medical devices. We propose that the incorporation of FXIIIa inhibitors into catheters, stents, and other medical implant devices would reduce the incidence of catheter sheath formation, thrombotic occlusion, and associated staphylococcal infection. This technique could be used as a local delivery system for extended release with an immediate onset of action for other poorly aqueous soluble compounds.

Item Type:Journal article
Keywords:Central venous catheter, Catheter-related complications, Catheter-related infection, Catheter-related thrombosis, Transglutaminase, FXIIIa inhibitor
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:39121
Deposited By: Dr Deborah Lowry
Deposited On:02 Jan 2018 14:47
Last Modified:02 Jan 2018 14:47

Repository Staff Only: item control page