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The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents

Pantic, JM, Jovanovic, IP, Radosavljevic, GD, Arsenijevic, NN, Conlon, JM and Lukic, ML (2017) The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents. Molecules, 22 (12). E2071-E2071. [Journal article]

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DOI: 10.3390/molecules22122071


The aim of this article is to review the immunoregulatory actions of frog skin-derived peptides in order to assess their potential as candidates for immunomodulatory or anti-inflammatory therapy. Frog skin peptides with demonstrable immunomodulatory properties have been isolated from skin secretions of a range of species belonging to the families Alytidae, Ascaphidae, Discoglossidae,Leptodactylidae,PipidaeandRanidae. Theireffectsuponproductionofinflammatory and immunoregulatory cytokines by target cells have been evaluated ex vivo and effects upon cytokine expression and immune cell activity have been studied in vivo by flow cytometry after injectionintomice. Thenaturally-occurringpeptidesand/ortheirsyntheticanaloguesshowcomplex and variable actions on the production of proinflammatory (TNF-α, IL-1β, IL-12, IL-23, IL-8, IFN-γ and IL-17), pleiotropic (IL-4 and IL-6) and immunosuppressive (IL-10 and TGF-β) cytokines by peripheral and spleen cells, peritoneal cells and/or isolated macrophages. The effects of frenatin 2.1S include enhancement of the activation state and homing capacity of Th1-type lymphocytes and NK cells in the mouse peritoneal cavity, as well as the promotion of their tumoricidal capacities. Overall, the diverse effects of frog skin-derived peptides on the immune system indicate their potential for development into therapeutic agents.

Item Type:Journal article
Keywords:frog skin peptides; host defence peptides; immunomodulatory; cytokine; antimicrobial
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Arts > School of Media, Film & Journalism
Faculty of Life and Health Sciences
Faculty of Arts
Research Institutes and Groups:Centre for Media Research
ID Code:39188
Deposited By: Dr Nigel Irwin
Deposited On:02 Jan 2018 14:48
Last Modified:13 Dec 2018 23:23

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