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Gut microbiota composition correlates with diet and health in the elderly

Claesson, Marcus J, Jeffery, Ian B, Conde, Susana, Power, Susan E, O' Connor, Eibhlis M, Cusack, Siobhan, Harris, Hugh M B, Coakley, Mairead, Lakshminarayanan, Bhuvaneswari, O' Sullivan, Orla, Fitzgerald, Gerald F, Deane, Jennifer, O' Connor, Michael, Harnedy, Norma, O' Connor, Kieran, O' Mahony, Denis, van Sinderen, Douwe, Wallace, Martina, Brennan, Lorraine, Stanton, Catherine, Marchesi, Julian R, Fitzgerald, Anthony P, Shanahan, Fergus, Hill, Colin, Ross, R Paul and O' Toole, Paul W (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature, 488 . [Journal article]

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URL: https://www.nature.com/articles/nature11319.pdf

DOI: doi:10.1038/nature11319

Abstract

Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clusteringof subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty.Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

Item Type:Journal article
Keywords:Gut microbiota, Elderly
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Genomic Medicine
Biomedical Sciences Research Institute
ID Code:39196
Deposited By: Dr Jennifer Deane
Deposited On:02 Jan 2018 14:49
Last Modified:23 May 2018 11:56

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