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Optimising the glaucoma signal/noise ratio by mapping changes in spatial summation with area-modulated perimetric stimuli

Rountree, Lindsay, Mulholland, Pádraig J., Anderson, Roger S., Garway-Heath, David F. and Redmond, Tony (2018) Optimising the glaucoma signal/noise ratio by mapping changes in spatial summation with area-modulated perimetric stimuli. Scientific Reports, 8 (1). p. 2172. [Journal article]

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URL: https://www.nature.com/articles/s41598-018-20480-4

DOI: 10.1038/s41598-018-20480-4

Abstract

Identification of glaucomatous damage and progression by perimetry are limited by measurementand response variability. This study tested the hypothesis that the glaucoma damage signal/noiseratio is greater with stimuli varying in area, either solely, or simultaneously with contrast, than with conventional stimuli varying in contrast only (Goldmann III, GIII). Thirty glaucoma patients and 20 age-similar healthy controls were tested with the Method of Constant Stimuli (MOCS). One stimulus modulated in area (A), one modulated in contrast within Ricco’s area (CR), one modulated in both area and contrast simultaneously (AC), and the reference stimulus was a GIII, modulating in contrast. Stimuli were presented on a common platform with a common scale (energy). A three-stage protocol minimised artefactual MOCS slope bias that can occur due to differences in psychometric function sampling between conditions. Threshold difference from age-matched normal (total deviation), response variability, and signal/noise ratio were compared between stimuli. Total deviation was greater with, and response variability less dependent on defect depth with A, AC, and CR stimuli, compared with GIII. Both A and AC stimuli showed a significantly greater signal/noise ratio than the GIII, indicating that area-modulated stimuli offer benefits over the GIII for identifying early glaucoma and measuring progression.

Item Type:Journal article
Keywords:Glaucoma, Perimetry, Spatial summation
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Optometry and Vision Science
ID Code:39614
Deposited By: Dr Padraig Mulholland
Deposited On:06 Mar 2018 11:24
Last Modified:06 Mar 2018 11:24

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