Nomikou, Nikolitsa and McHale, Anthony (2009) Electrokinetic dispersion of a cancer chemotherapeutic drug for the treatment of solid tumours. CANCER LETTERS, 279 (2). pp. 202-208. [Journal article]
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Compromised turnout vascularisation presents a significant challenge to chemotherapeutic-based treatment of solid tumours. In this study we use subtle electric field characteristics to facilitate electrokinetic movement of a cancer chemotherapeutic agent in an ionically complex environment. We demonstrate that such an approach can be exploited to facilitate the electrokinetic movement of camptothecin from a peritumoural site through otherwise relatively impermeable turnout tissues. Here we demonstrate enhanced antitumour effects using this approach in a pre-clinical model for solid tumours and suggest one possible therapeutic application of the approach in the treatment of lung cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science|
Faculty of Life and Health Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
|Deposited By:||Professor Anthony McHale|
|Deposited On:||18 Dec 2009 14:40|
|Last Modified:||04 Dec 2012 11:18|
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