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Emerging therapeutic potential for xenin and related peptides in obesity and diabetes

Craig, SL, Gault, Victor A and Irwin, Nigel (2018) Emerging therapeutic potential for xenin and related peptides in obesity and diabetes. Diabetes Metabolism Research and Reviews, N/A . xx-xx. [Journal article]

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DOI: https://doi.org/10.1002/dmrr.3006

Abstract

Xenin‐25 is a 25 amino acid peptide hormone co‐secreted from the same enteroendocrine K‐cell as the incretin peptide glucose‐dependent insulinotropic polypeptide (GIP). There is no known specific receptor for xenin‐25, but studies suggest that at least some biological actions may be mediated through interaction with the neurotensin receptor. Original investigation into the physiological significance of xenin‐25 focussed on effects related to gastrointestinal transit and satiety. However, xenin‐25 has been demonstrated in pancreatic islets and recently shown to possess actions in relation to the regulation of insulin and glucagon secretion, as well as promoting beta‐cell survival. Accordingly, the beneficial impact of xenin‐25, and related analogues, has been assessed in animal models of diabetes‐obesity. In addition, studies have demonstrated that metabolically active fragment peptides of xenin‐25, particularly xenin‐8, possess independent therapeutic promise for diabetes, as well as serving as bioactive components for the generation of multi‐acting hybrid peptides with antidiabetic potential. This review will focus on continuing developments with xenin compounds in relation to new therapeutic approaches for diabetes‐obesity.

Item Type:Journal article
Keywords:Xenin-25; glucose-dependent insulinotropic polypeptide (GIP); insulin secretion; satiety; diabetes
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
Biomedical Sciences Research Institute > Diabetes
ID Code:39928
Deposited By: Dr Nigel Irwin
Deposited On:13 Apr 2018 15:14
Last Modified:06 Apr 2019 22:23

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