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Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

Callan, J, McEwan, C, Owen, J, Stride, E, Fowley, Colin, Nesbitt, Heather, Cochrane, D, Coussios, CC, Borden, M, Nomikou, N and McHale, AP (2015) Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. Journal of Controlled Release, 203 . pp. 51-56. [Journal article]

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Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using these techniques. The ability to deliver oxygen to the vicinity of the tumour increases its local partial pressure improving the possibility of ROS generation in PDT/SDT. In this manuscript, we investigate the use of oxygen-loaded, lipid-stabilised microbubbles(MBs),decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo. We directly compare the effectiveness of the oxygen-loaded MBs with sulphur hexafluoride (SF6)-loaded MBs and reveal a significant improvement in therapeutic efficacy. The combination of oxygen-carrying, ultrasound-responsive MBs, with an ultrasound-responsive therapeutic sensitiser, offers the possibility of delivering and activating the MB-sensitiser conjugate at the tumour site in a non-invasive manner, providing enhanced sonodynamic activation at that site.

Item Type:Journal article
Keywords:Hypoxia; Microbubbles; SDT; Rose Bengal; Cancer; Pancreatic
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences
ID Code:39969
Deposited By: Professor John Callan
Deposited On:23 Apr 2018 14:22
Last Modified:23 Apr 2018 14:22

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