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Incorporation of Siderophore Binding Sites in a Dipodal Fluorescent Sensor for Fe(III)

Singh, Narinder, Kaur, Navneet and Callan, John F. (2009) Incorporation of Siderophore Binding Sites in a Dipodal Fluorescent Sensor for Fe(III). JOURNAL OF FLUORESCENCE, 19 (4). pp. 649-654. [Journal article]

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DOI: 10.1007/s10895-008-0457-4

Abstract

A new fluorescent probe 3, has been developed for the detection of Fe(III) in water based samples. The design of 3 involved the incorporation of Fe(III) binding sites observed in naturally occurring Siderophores into a synthetic sensing assembly. The probe, containing two Schiff base receptors connected to a mesitylene platform, was prepared in two steps. The dipodal sensor displayed good selectivity for Fe(III) when tested against other physiological and environmentally important metal ions, in HEPES buffered solution at pH 7.0, through a quenching of the fluorescent intensity. Stern-Volmer analysis of this quenching interaction indicated a 1:1 (host : guest) binding stoichiometry between the probe and Fe(III). The association constant, K (a) calculated using the Benesi-Hildebrand equation was found to be 3.8 x 10(4) M-1. Crucially, the sensor was capable of measuring Fe(III) competitively in solutions containing both Fe(III) and Cu(II). Thus, the adoption of Fe(III) binding sites found in nature, into synthetic luminescent assemblies has proven an effective design strategy for the development of new Fe(III) probes.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Faculty of Life and Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:4056
Deposited By: Professor John Callan
Deposited On:05 Jan 2010 14:11
Last Modified:19 Nov 2012 15:20

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