McKeown, SR, Ward, C and Robson, T (2004) Gene-directed enzyme prodrug therapy: A current assessment. CURRENT OPINION IN MOLECULAR THERAPEUTICS, 6 (4). pp. 421-435. [Journal article]
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Abstract
Gene-directed enzyme prodrug therapy involves tumor-specific delivery of a gene encoding a drug-metabolizing enzyme allowing metabolism of a non-toxic prodrug to a toxic species directly within tumor cells. This review covers the wide range of enzyme-prodrug combinations currently under preclinical and clinical investigation. Issues of tumor specificity and enhanced cytotoxicity through bystander effects will be discussed.
Item Type: | Journal article |
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Faculties and Schools: | Faculty of Life and Health Sciences Faculty of Life and Health Sciences > School of Biomedical Sciences |
Research Institutes and Groups: | Biomedical Sciences Research Institute Biomedical Sciences Research Institute > Pharmacy & Pharmaceutical Sciences |
ID Code: | 4317 |
Deposited By: | Professor Stephanie McKeown |
Deposited On: | 21 Dec 2009 12:02 |
Last Modified: | 01 Jun 2011 15:49 |
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