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Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus

Choi, SW, Benzie, IFF, Lam, CSY, Chat, SWS, Lam, J, Yiu, CH, Kwan, JJ, Tang, YH, Yeung, GSP, Yeung, VTF, Woo, GC, Hannigan, BM and Strain, JJ (2005) Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus. DIABETIC MEDICINE, 22 (10). pp. 1347-1353. [Journal article]

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DOI: 10.1111/j.1464-5491.2005.01647.x


Aims The onset of complications in Type 2 diabetes mellitus (DM) patients cannot be predicted in individuals. Evidence suggests a link between complications and hyperglycaemia, oxidative stress and antioxidants, but causality is unclear. This study investigated baseline (entry) fasting plasma ascorbic acid, lymphocytic DNA damage and glycaemic control in Type 2 DM as part of a long-term study, the aim of which is to explore a biomarker profiling approach to identify and improve outcome in high-risk subjects. Methods A cross-sectional study, in which DNA damage, glycated haemoglobin (HbA(1c)), fasting plasma glucose (FPG) and ascorbic acid (AA) were measured on fasting blood samples collected from 427 Type 2 DM subjects. Results DNA damage was significantly (P < 0.0001) and directly correlated to both FPG (r = 0.540) and HbA(1c) (r = 0.282), and was significantly (P < 0.0001), independently and inversely correlated to plasma AA (r = -0.449). In those subjects with both poor glycaemic control and low AA (< 48 mu M, the overall mean value for the study group), DNA damage was significantly (P < 0.005) higher compared with those subjects with a similar degree of hyperglycaemia but with AA above the mean. Conclusions The novel finding of a significant inverse relationship between plasma AA and DNA damage in Type 2 DM indicates that poorly controlled diabetic subjects might benefit from increased dietary vitamin C. The data also have important implications for biomarker profiling to identify those subjects who might benefit most from intensive therapy. Longer-term follow-up is underway.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:5172
Deposited By: Mrs Alison Deehan
Deposited On:14 Jan 2010 14:37
Last Modified:01 Nov 2011 11:55

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