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Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water

Araya, M, McGoldrick, MC, Klevay, LM, Strain, JJ, Robson, P, Nielsen, F, Olivares, M, Pizarro, F, Johnson, L and Poirier, KA (2001) Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 34 (2). pp. 137-145. [Journal article]

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DOI: 10.1006/rtph.2001.1492


A prospective, double-blind controlled study was designed to determine the acute no-observed-adverse-effect level (NOAEL) of nausea in an apparently healthy population of 179 individuals who drank copper-containing water as the sulfate salt. Subjects were recruited at three different international sites and given a blind, randomly selected dose (0, 2, 4, 6, or 8 mg Cu/L) in a bolus of 200 ml (final total copper dose was equivalent to 0, 0.4,0.8,1.2, and 1.6 mg) once weekly over a consecutive 5-week period. Gastrointestinal (GI) symptoms of nausea, abdominal pain, vomiting, or diarrhea were screened for a period of up to 24 h. Nausea was the most frequently reported effect and was reported within the first 15 min of ingestion. For the combined trisite population (n=179),8,9,14,25, and 44 subjects responded positively to one or more GI symptoms at 0, 2, 4, 6, and 8 mg Cu/L, respectively. Analysis of the data demonstrated a clear dose response to the combined positive GI effects and to nausea alone. Statistically significant greater reporting of effects occurred at 6 and 8 mg Cu/L. Therefore, an acute NOAEL and lowest-observed-adverse-effect level of 4 and 6 mg Cu/L (0.8 and 1.2 mg Cu), respectively, were determined in drinking water for a combined international human population. (C) 2001 Academic Press.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:5212
Deposited By: Mrs Alison Deehan
Deposited On:14 Jan 2010 14:45
Last Modified:01 Nov 2011 11:10

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