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Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study

Simonsen, N, van't Veer, P, Strain, JJ, Martin-Moreno, JM, Huttunen, JK, Navajas, JFC, Martin, BC, Thamm, M, Kardinaal, AFM, Kok, FJ and Kohlmeier, L (1998) Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. American Journal of Epidemiology, 147 (4). pp. 342-352. [Journal article]

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The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast cancer and that the degree of inhibition depends on background levels of omega-6 polyunsaturates. Considered in isolation, the level of omega-3 or omega-8 fat in adipose tissue displayed little consistent association with breast cancer across study centers, The ratio of long-chain omega-3 fatty acids to total omega-6 fat showed an inverse association with breast cancer in four of five centers. In Malaga, Spain, the odds ratio for the highest tertile relative to the lowest reached 0.32 (95% confidence interval 0.13-0.82), In this center, total omega-6 fatty acid was strongly associated with breast cancer, With all centers pooled, the odds ratio for long-chain omega-3 to total omega-8 reached 0.80 for the second tertile and 0.65 for the third tertile, a downward trend bordering on statistical significance (p for trend = 0.055), While not definitive, these results provide evidence for the hypothesis that the balance between omega-3 and omega-8 fat may play a role in breast cancer.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:5264
Deposited By: Mrs Alison Deehan
Deposited On:14 Jan 2010 14:59
Last Modified:22 Aug 2012 09:26

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