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Thyroid hormones and selenium status in breast cancer

Strain, JJ (1997) Thyroid hormones and selenium status in breast cancer. Nutrition and Cancer - An International Journal, 27 (1). pp. 48-52. [Journal article]

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Within a case-control study of postmenopausal breast cancer patients (n = 99) and matched healthy controls (n = 105), thyroid hormone levels were compared and correlated with toenail selenium concentrations. Plasma triiodothyronine (T-3) was significantly lower in cases (1.4 +/- 0.4 nmol/l) than in controls (1.6 +/- 0.4 nmol/l), and a strong inverse relationship with breast cancer was observed with an odds ratio of 0.17 (95% CI = 0.08-0.36) in the highest compared with the lowest tertile of T-3. Plasma thyroxine and thyroid-stimulating hormone concentrations were similar between cases and controls. Plasma T-3 concentration was positively associated with toenail selenium in cases (age-adjusted regression coefficient = 0.049) and controls (age-adjusted regression coefficient = 0.036). Toenail selenium concentrations tended to be lower in cases than in controls, but the differences did not Peach statistical significance. Although the disease process per se may explain the lower plasma T-3 concentrations, it is also possible, inasmuch as these patients were in early-stage breast cancer, that selenium status may be influencing T-3 levels via changes in the activity of the selenoenzyme type I iodothyronine deiodinase.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:5275
Deposited By: Mrs Alison Deehan
Deposited On:14 Jan 2010 15:02
Last Modified:22 Aug 2012 09:44

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