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Cholesterol screening and family history of vascular disease

Primrose, ED, Savage, JM, Boreham, CA, Cran, GW and Strain, JJ (1994) Cholesterol screening and family history of vascular disease. Archives of Disease in Childhood, 71 (3). pp. 239-242. [Journal article]

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Hypercholesterolaemia is a major risk factor for the development of coronary heart disease (CHD). Early detection and management of hypercholesterolaemia could retard the atherosclerotic process. Given that CHD and hypercholesterolaemia cluster within families, a screening strategy based on a family history of vascular disease has been advocated. Serum total cholesterol concentrations were measured in a random stratified sample of 1012 children aged from 12-15 years old participating in a coronary risk factor surveillance Ireland. Information disease in close family members was obtained by means of a questionnaire. The study population was divided into two groups according to total cholesterol values: (i) normal, <5.2 mmol/l (n=822) and (ii) raised, greater than or equal to 5.2 mmol/l (n=190). A family history identified 63 out of 190 individuals with hypercholesterolaemia yielding a sensitivity of 33.2% and specificity of 71.5%. Our data indicated that a strategy whereby only children from high risk families are screened for hypercholesterolaemia is ineffective. While primary prevention emphasising a healthy diet for all is essential, the role of universal screening deserves further appraisal.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:5292
Deposited By: Mrs Alison Deehan
Deposited On:14 Jan 2010 15:12
Last Modified:22 Aug 2012 09:59

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