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Captopril and its synthesis from chiral intermediates

Chirumamilla, RR, Marchant, R and Singh - Nee Nigam, Poonam (2001) Captopril and its synthesis from chiral intermediates. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 76 (2). pp. 123-127. [Journal article]

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Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin-angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. (C) 2001 Society of Chemical Industry.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Infection and Immunity/Microbiology
Biomedical Sciences Research Institute
ID Code:5500
Deposited By: Dr Poonam Singh - Nee Nigam
Deposited On:21 Dec 2009 10:56
Last Modified:04 Aug 2011 08:48

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