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Acute exercise and impaired glucose tolerance in obese humans

McClean, Conor, McNeilly, Andrea, Trinick, Tom, R., Murphy, Marie, Duly, Ellie, McLaughlin, James, McEneny, Jane, Burke, George and Davison, Gareth (2009) Acute exercise and impaired glucose tolerance in obese humans. Journal of Clinical Lipidology, 3 (4). pp. 262-268. [Journal article]

[img] Other (Acute Exercise and IGT Final version) - Accepted Version
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DOI: 10.1016/j.jacl.2009.07.001


Background: Individuals with impaired glucose tolerance (IGT) have a greater risk of developing diabetes and cardiovascular disease compared to those with normal glycaemic control. The aim of this study was to examine the effects of acute aerobic exercise on glycaemia, regional arterial stiffness and oxidative stress in obese subjects with IGT. Design: Twelve obese subjects (7 males and 5 females; 48.0 ± 9.4 yrs; BMI 32.4 ± 7.0 kg/m2) with IGT participated in a 30 minute bout of walking at 65% of maximum predicted heart rate (HR). Pulse wave velocity (PWV, for determination of arterial stiffness) and blood pressure (BP) were examined pre and post exercise, while venous blood samples were drawn for determination of glucose, blood lipids and indices of oxidative stress and inflammation (lipid hydroperoxides – LOOH; superoxide dismutase – SOD; hs-CRP – high sensitivity C-reactive protein). Results: Post exercise PWV (9.1 ± 1.2 m/sec vs. 8.6 ± 1.0 m/sec), glucose (5.7 ± 0.6 mmol∙L-1 vs. 5.4 ± 0.6 mmol∙L-1) and diastolic BP (94 ± 14 mmHg vs. 86 ± 13 mmHg) decreased, respectively (P < 0.05). A correlation was observed between PWV and glucose (r = 0.544, P < 0.05). There were no changes in LOOHs, SOD, hs-CRP or blood lipids, respectively (P > 0.05). Conclusions: These findings suggest that acute aerobic exercise can reduce regional arterial stiffness in obese subjects with IGT by possibly improving glucose metabolism, independent of changes in oxidative stress.

Item Type:Journal article
Keywords:Walking; Impaired glucose tolerance; Regional stiffness; Pulse wave velocity; Obesity
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Sport
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
Sport and Exercise Sciences Research Institute
Sport and Exercise Sciences Research Institute > Centre for Physical Activity and Health
ID Code:6094
Deposited By: Dr Conor McClean
Deposited On:04 Feb 2010 13:45
Last Modified:29 Oct 2012 12:32

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