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Direct DNA hybridization at disposable graphite electrodes modified with carbon nanotubes

Erdem, A, Papakonstantinou, P and Murphy, H (2006) Direct DNA hybridization at disposable graphite electrodes modified with carbon nanotubes. ANALYTICAL CHEMISTRY, 78 (18). pp. 6656-6659. [Journal article]


DOI: 10.1021/ac060202z


The performance of glassy carbon ( GCE) and graphite pencil electrodes (PGE) modified with multiwalled carbon nanotubes (CNTs) are compared, based on the direct electrochemical detection of nucleic acids. This is accomplished by monitoring the differential pulse voltammetry changes of the guanine signal. CNT-modified PGE compares favorably to that of the commonly used CNT-modified GCE owing to the intrinsic improved performance of the supporting PGE. The better intrinsic characteristics of the PGE are related to its composite structure and higher level of porosity compared to GCE. The performance characteristics of the direct DNA hybridization on the disposable CNT-modified PGE are studied in terms of optimum analytical conditions such as probe concentration, target concentration, hybridization time, and selectivity. The new DNA biosensor described here has shown some important advantages such being inexpensive, sensitive, selective, and able to generate reproducible results using a simple and direct electrochemical protocol.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:6402
Deposited By: Professor Pagona Papakonstantinou
Deposited On:13 Jan 2010 10:55
Last Modified:17 Oct 2017 15:40

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