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Predicting Successful Transthoracic Cardioversion by Dominant Atrial Fibrillatory Frequency Analysis: The Effects of Bisoprolol

Diaz, J, Escalona, OJ, Castro, NC, Anderson, JMCC, Glover, BM and Manoharan, G (2009) Predicting Successful Transthoracic Cardioversion by Dominant Atrial Fibrillatory Frequency Analysis: The Effects of Bisoprolol. In: The World Congress on Medical Physics and Biomedical Engineering, 2009., Munich, Germany. UNSPECIFIED. 4 pp. [Conference contribution]

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The most common strategies in the managementof atrial fibrillation (AF) involve electrical cardioversion andpharmacological agents. Bisoprolol is a high selective β1-adrenoceptor blocker used for ventricular rate control and tohelp maintain sinus rhythm. In a retrospective study we comparedECG frequency domain variables between patients whounderwent a successful electrical cardioversion and those thatwere unsuccessful. As well as this we assessed whether therewas a difference in these variables for patients who underwent electrical cardioversion while on bisoprolol. Signal processingwas performed on 51 patients undergoing electrical cardioversion:bandpass filtering (0.5-50Hz), QRST cancellation andfrequency analysis. An incremental defibrillation energy protocolwas delivered until cardioversion or up to a maximumlevel of 200 [J]. The study indicated a significant difference inthe dominant AF frequency for long segments (DAFF_L) betweencardioverted and non-cardioverted subgroups, employingan energy less or equal to 100 Joules respectively: (5.5391 ±1.0396) [Hz] vs. (6.0859 ±0.8071) [Hz] (n=48, p = 0.048), and inpatients on bisoprolol: (5.5250 ±1.0302) [Hz] vs. (6.4489±0.5828) [Hz] (n=26, p = 0.008). Also, the energy required forsuccessful cardioversion was significantly lower for patients onbisoprolol: (110.00 ± 27.77) [J] vs. (129.41 ±30.92) [J], p=0.046.Also, there was a positive correlation between the DAFF_Land the minimal energy necessary for successful cardioversion( =0.434, p=0.007); a better correlation was obtained for patientson bisoprolol ( =0.575, p=0.005). Therefore, analysis ofDAFF_L on Lead II can be a useful indicator for predictingdefibrillation success in AF patients undergoing transthoracicelectric cardioversion, and there is a positive incidence of Bisoprololupon the values of DAFF_L and electrical cardioversionsuccess at minimal shock energy.

Item Type:Conference contribution (Paper)
Keywords:Atrial fibrillation cardioversion, atrial fibrillatory frequency, Bisoprolol effects, QRS complex cancellation
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:6552
Deposited By: Professor Omar Escalona
Deposited On:12 Jan 2010 15:23
Last Modified:09 Dec 2015 10:05

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