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Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study

Intorre, F, Polito, A, Andriollo-Sanchez, M, Azzini, E, Raguzzini, A, Toti, E, Zaccaria, M, Catasta, G, Meunier, N, Ducros, V, O'Connor, JM, Coudray, C, Roussel, AM and Maiani, G (2008) Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 62 (10). pp. 1215-1223. [Journal article]

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DOI: 10.1038/sj.ejcn.1602844


Objective: To assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. Subjects/Methods: Three hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and alpha-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation. Results: Plasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, P<0.05; for 30 mg Zn/day, P<0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates. Conclusions: Our results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:7171
Deposited By: Professor Jacqueline McCormack
Deposited On:18 Jan 2010 11:29
Last Modified:15 Dec 2011 14:40

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