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Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH

Polito, A, Intorre, F, Andriollo-Sanchez, M, Azzini, E, Raguzzini, A, Meunier, N, Ducros, V, O'Connor, JM, Coudray, C, Roussel, AM and Maiani, G (2005) Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 59 (Suppl.). S42-S47. [Journal article]

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DOI: 10.1038/sj.ejcn.1602297


Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Nutrition Innovation Centre for Food and Health (NICHE)
Biomedical Sciences Research Institute
ID Code:7183
Deposited By: Professor Jacqueline McCormack
Deposited On:18 Jan 2010 11:34
Last Modified:15 Dec 2011 16:02

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