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Number of items: 66.


Nesbitt, Heather, Worthington, Jenny, Errington, Rachel J., Patterson, Laurence H., Smith, Paul J., McKeown, Stephanie and McKenna, Declan (2017) The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors. The Prostate, 77 (15). pp. 1539-1547. [Journal article]


Byrne, NM, Nesbitt, Heather, Ming, L, McKeown, Stephanie, Worthington, Jenny and McKenna, Declan (2016) Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition. British Journal of Cancer, epub . [Journal article]

Nesbitt, Heather, Byrne, Niall, Ming, Louise, Worthington, Jenny, Errington, Rachel, Patterson, Laurence, Smith, Paul, McKeown, Stephanie and McKenna, Declan (2016) Targeting hypoxic prostate tumours using the novel hypoxia-activated prodrug OCT1002 inhibits expression of genes associated with malignant expression. Ulster Medical Journal, 86 (1). p. 11. [Journal article]

Nesbitt, Heather, Byrne, Niall M., Williams, S. Nicole, Ming, Louise, Worthington, Jenny, Errington, Rachel J., Patterson, Laurence H., Smith, Paul J., McKeown, Stephanie and McKenna, Declan (2016) Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression. Clinical Cancer Research, 2016 . [Journal article]


Nesbitt, Heather, Browne, Gillian, O'Donovan, Katie M., Byrne, Niall M., Worthington, Jenny, McKeown, Stephanie and McKenna, Declan J (2015) Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo. Journal of Cellular Physiology, 231 (2). pp. 473-482. [Journal article]

Nesbitt, Heather, byrne, niall, Worthington, Jenny, McKeown, Stephanie and McKenna, Declan (2015) Targeting hypoxia in prostate cancer cells to increase treatment efficacy. Ulster Medical Journal, 84 (3). pp. 209-210. [Journal article]

O'Donovan, Katie, Nesbitt, Heather, McKeown, Stephanie, Camac, Nicole and McKenna, Declan (2015) Characterization of 22RV1-Luc xenograft response to androgen-deprivation therapy. In: 2015 Keystone Symposia Conference E3: Hypoxia: From Basic Mechanisms to Therapeutics, Dublin, Ireland. Keystone Symposia. 100 pp. [Conference contribution]

Smith, Paul, Wiltshire, Marie, Nesbitt, Heather, Byrne, Niall, Ming, Louise, McKenna, Declan, Worthington, Jenny, McKeown, Stephanie, Patterson, Laurence and Errington, Rachel (2015) Cytometry of Anticancer Prodrug OCT1002 Activation and Targeting Using In Vitro and In Vivo Models of Tumour Hypoxia. In: CYTO 2015, the 30th Congress of the International Society for Advancement of Cytometry, Glasgow,Scotland. International Society for Advancement of Cytometry. 268 pp. [Conference contribution]

cochrane, david, o'donovan, katie, Nesbitt, Heather, McKeown, Stephanie, Worthington, Jenny, o'rourke, martin, James, Iain and McKenna, Declan (2015) Characterisation of novel AKT inhibitor in treatment of androgen sensitive prostate cancer. In: Irish Association for Cancer Research 2015, Limerick. Irish Association for Cancer Research. 180 pp. [Conference contribution]


Rashid, Shazia, Unyayar, Ali, Mazmanci, Mehmet Ali, McKeown, Stephanie R., Worthington, Jenny and Banat, Ibrahim (2014) Potential of a Funalia trogii laccase enzyme as an anticancer agent. Ann Microbiol (2015) 65:175–183, 65 . pp. 175-183. [Journal article]


Bowman, Karen J, Al-Moneef, Manar M, Sherwood, Benedict T, Colquhoun, Alexandra J, Goddard, Jonathan C, Griffiths, T R Leyshon, Payne, David, Singh, Sadmeet, Butterworth, Paul C, Khan, Masood A, Summerton, Duncan J, Steward, William P, McKelvey-Martin, Valerie J, McKeown, Stephanie, Kockelbergh, Roger C, Mellon, J Kilian, Symonds, R Paul and Jones, George D D (2013) Comet assay measures of DNA damage are predictive of bladder cancer cell treatment sensitivityin vitroand outcomein vivo. International Journal of Cancer, TBC . n/a. [Journal article]

Ming, L, Byrne, N, Camac, SN, Ward, C, Mitchell, Christopher, Waugh, D, McKeown, Stephanie and Worthington, Jenny (2013) Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours; informed scheduling of the bioreductive drug AQ4N improves treatment response. International Journal of Cancer, 132 . pp. 1323-1332. [Journal article]


Browne, G, Nesbitt, H, Ming, L, Stein, GS, Lian, JB, McKeown, SR and Worthington, Jenny (2012) Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance. British Journal of Cancer, 107 . pp. 1714-1721. [Journal article]

McKenna, Declan J, Doherty, Bernadette, Downes, Stephen, McKeown, SR and McKelvey-Martin, Valerie J (2012) Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation. PLoS ONE, 7 (11). e49364. [Journal article]


Worthington, Jenny, McKeown, Stephanie and Banat, Ibrahim (2011) A study of anti-cancer effects of Funalia trogii in vitro and in vivo. Food and Chemical Toxicology, 49 (7). pp. 1477-1483. [Journal article]


Devlin, Andrea, Thompson, Paul, Robson, Tracy and McKeown, SR (2010) Cytochrome P450 1B1 mRNA Untranslated Regions Interact to Inhibit Protein Translation. Molecular Carcinogenesis, 49 (2). pp. 190-199. [Journal article]


Devlin, Andrea, Mcllroy, Marie, McKeen, Hayley D., Bonde, Pramode, Menezes, A. A. Carlos, Swarbrick, Christine J., Robson, Tracy, Hirst, David G., Campbell, F. Charles, McGuigan, James A. and McKeown, Stephanie (2009) Cytochrome P450 1B1 Expression in Rat Esophageal Tumorigenesis Promoted by Gastric and Duodenal Reflux. MOLECULAR CARCINOGENESIS, 48 (2). pp. 110-117. [Journal article]


Butterworth, Karl T, McCarthy, Helen O, Devlin, Andrea, Ming, Louise, Robson, Tracy, McKeown, Stephanie and Worthington, Jenny (2008) Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype. INTERNATIONAL JOURNAL OF CANCER, 123 (4). pp. 760-768. [Journal article]

McKenna, Declan, McKeown, Stephanie and McKelvey-Martin, Valerie J (2008) Potential use of the comet assay in the clinical management of cancer. Mutagenesis, 23 (3). pp. 183-190. [Journal article]

O'Keeffe, Martina B, Devlin, Andrea, Burns, Alan J, Gardiner, Tom A, Logan, Ian, Hirst, David G and McKeown, Stephanie (2008) Investigation of pericytes, hypoxia, and vascularity in bladder tumors: Association with clinical outcomes. ONCOLOGY RESEARCH, 17 (3). pp. 93-101. [Journal article]

O'Rourke, Martin, Ward, Claire, Worthington, Jenny, McKenna, Julie, Valentine, Andrea, Robson, Tracy, Hirst, David G and McKeown, Stephanie (2008) Evaluation of the antiangiogenic potential of AQ4N. CLINICAL CANCER RESEARCH, 14 (5). pp. 1502-1509. [Journal article]

Wilson, C, Scullin, P, Worthington, Jenny, Seaton, A, Maxwell, P, O'Rourke, D, Johnston, PG, McKeown, Stephanie, Wilson, RH, O'Sullivan, JM and Waugh, DJJ (2008) Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer. BRITISH JOURNAL OF CANCER, 99 (12). pp. 2054-2064. [Journal article]


McCarthy, HO, Worthington, Jenny, Barrett, E, Cosimo, E, Boyd, M, Mairs, RJ, Ward, C, McKeown, Stephanie, Hirst, DG and Robson, T (2007) p(21(WAF1))-mediated transcriptional targeting of inducible nitric oxide synthase gene therapy sensitizes tumours to fractionated radiotherapy. GENE THERAPY, 14 (3). pp. 246-255. [Journal article]

McKeown, Stephanie, Cowen, RL and Williams, KJ (2007) Bioreductive drugs: from concept to clinic. CLINICAL ONCOLOGY, 19 (6). pp. 427-442. [Journal article]


Doherty, Sharon C, McKeown, SR, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie J (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. European Urology, 50 (2). pp. 290-301. [Journal article]

Doherty, Sharon C, McKeown, Stephanie R, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. EUROPEAN UROLOGY, 50 (2). pp. 290-301. [Journal article]

McIlroy, M, O'Rourke, M, McKeown, Stephanie, Hirst, DG and Robson, T (2006) Pericytes influence endothelial cell growth characteristics: Role of plasminogen activator inhibitor type 1 (PAI-1). CARDIOVASCULAR RESEARCH, 69 (1). pp. 207-217. [Journal article]

McKeown, SR and Jones, B (2006) DNA repair: therapeutic implications. The British Journal of Radiology, 79 (938). pp. 91-93. [Journal article]

Yakkundi, A, McErlane, V, Murray, M, McCarthy, HO, Ward, C, Hughes, Ciara, Patterson, LH, Hirst, DG, McKeown, Stephanie and Robson, T (2006) Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N. CANCER GENE THERAPY, 13 (6). pp. 598-605. [Journal article]


McErlane, V, Yakkundi, A, McCarthy, HO, Hughes, Ciara, Patterson, LH, Hirst, DG, Robson, T and McKeown, Stephanie (2005) A cytochrome P4502B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N. JOURNAL OF GENE MEDICINE, 7 (7). pp. 851-859. [Journal article]

Robson, T, Worthington, Jenny, McKeown, Stephanie and Hirst, DG (2005) Radiogenic therapy: Novel approaches for enhancing tumor radiosensitivity. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 4 (4). pp. 343-361. [Journal article]


McCarthy, HO, Worthington, Jenny, Ward, C, Barrett, E, Hirst, DG, McKeown, Stephanie and Robson, T (2004) Use of the p2l/WAF1 promoter for transcriptional targetting in cancer gene therapy. JOURNAL OF GENE MEDICINE, 6 (9). p. 78. [Journal article]

McKeown, SR, Ward, C and Robson, T (2004) Gene-directed enzyme prodrug therapy: A current assessment. CURRENT OPINION IN MOLECULAR THERAPEUTICS, 6 (4). pp. 421-435. [Journal article]


Doherty, SC, McKeown, Stephanie, McKelvey-Martin, Valerie, Downes, Stephen, Atala, A, Yoo, JJ, Simpson, DA and Kaufmann, WK (2003) Cell cycle checkpoint function in bladder cancer. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95 (24). pp. 1859-1868. [Journal article]

Dunne, AL, Price, ME, Mothersill, C, McKeown, Stephanie, Robson, T and Hirst, DG (2003) Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells. BRITISH JOURNAL OF CANCER, 89 (12). pp. 2277-2283. [Journal article]

McCarthy, Helen, Yakkundi, A, McErlane, V, Hughes, Ciara, Keilty, G, Murray, Margaret, Patterson, LH, Hirst, DG, McKeown, SR and Robson, T (2003) Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N. Cancer Gene Therapy, 10 (1). pp. 40-48. [Journal article]

McKenna, Declan J, Gallus, Massimo, McKeown, Stephanie, Downes, Stephen and McKelvey-Martin, Valerie (2003) Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells. DNA repair, 2 (8). pp. 879-90. [Journal article]

McKenna, Declan J, Rajab, Nor F, McKeown, Stephanie, McKerr, George and McKelvey-Martin, Valerie (2003) Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines. Radiation research, 159 (1). pp. 49-56. [Journal article]

McKeown, Stephanie, Robson, T, Price, ME, Ho, ETS, Hirst, DG and McKelvey-Martin, Valerie (2003) Potential use of the alkaline comet assay as a predictor of bladder tumour response to radiation. BRITISH JOURNAL OF CANCER, 89 (12). pp. 2264-2270. [Journal article]


McGreal, Stanley, Hughes, Ciara, Murray, Margaret, Friery, OP, Patterson, LH, Hirst, DG and McKeown, SR (2001) The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N. British Journal of Cancer, 85 (4). pp. 625-629. [Journal article]

McKeown, Stephanie, Hughes, Ciara, Keilty, Gillian, McCarthy, Helen, Murray, Margaret, Hirst, David and Robson, Tracy (2001) Manipulation of P450 gene expression in tumours; A novel approach for targeted activation of bioreductive prodrugs. In: Invited presentations on cancer. Nature Publishing Group. Vol 85 (Suppl.) 1 pp. [Conference contribution]


Al-Assar, O, Robson, T, McKeown, Stephanie, Gardin, I, Wilson, GD and Hirst, DG (2000) Regulation of FOS by different compartmental stresses induced by low levels of ionizing radiation. RADIATION RESEARCH, 154 (5). pp. 503-514. [Journal article]

Friery, OP, Gallagher, R, Murray, MM, Hughes, Ciara, Galligan, ES, McIntyre, Irene, Patterson, LH, Hirst, DG and McKeown, Stephanie (2000) Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine. BRITISH JOURNAL OF CANCER, 82 (8). pp. 1469-1473. [Journal article]

Martin, AR, Bailie, JR, Robson, T, McKeown, Stephanie, Al-Assar, O, McFarland, A and Hirst, DG (2000) Retinal pericytes control expression of nitric oxide synthase and endothelin-1 in microvascular endothelial cells. MICROVASCULAR RESEARCH, 59 (1). pp. 131-139. [Journal article]

Patterson, LH and McKeown, Stephanie (2000) AQ4N: a new approach to hypoxia-activated cancer chemotherapy. BRITISH JOURNAL OF CANCER, 83 (12). pp. 1589-1593. [Journal article]

Patterson, LH, McKeown, Stephanie, Ruparella, K, Double, JA, Bibby, MC, Cole, S and Stratford, IJ (2000) Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. BRITISH JOURNAL OF CANCER, 82 (12). pp. 1984-1990. [Journal article]

Price, ME, McKelvey-Martin, Valerie, Robson, T, Hirst, DG and McKeown, Stephanie (2000) Induction and rejoining of DNA double-strand breaks in bladder tumor cells. RADIATION RESEARCH, 153 (6). pp. 788-794. [Journal article]

Robson, T, Price, ME, Moore, ML, Joiner, MC, McKelvey-Martin, Valerie, McKeown, Stephanie and Hirst, DG (2000) Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76 (5). pp. 617-623. [Journal article]

Ruddock, MW, Burns, DM, McKeown, Stephanie, Murphy, L, WAlsh, IK, Keane, PF and Hirst, DG (2000) Contractile properties of human renal cell carcinoma recruited arteries and their response to nicotinamide. RADIOTHERAPY AND ONCOLOGY, 54 (2). pp. 179-184. [Journal article]


Patterson, LH, McKeown, Stephanie, Robson, T, Gallagher, R, Raleigh, SM and Orr, S (1999) Antitumour prodrug development using cytochrome P450 (CYP) mediated activation. ANTI-CANCER DRUG DESIGN, 14 (6). pp. 473-486. [Journal article]

Robson, T, Joiner, MC, Wilson, GD, McCullough, William, Price, ME, Logan, Ian, Jones, H, McKeown, Stephanie and Hirst, DG (1999) A novel human stress response-related gene with a potential role in induced radioresistance. RADIATION RESEARCH, 152 (5). pp. 451-461. [Journal article]


McKelvey-Martin, Valerie, Ho, ETS, McKeown, Stephanie, Johnston, SR, McCarthy, PJ, Rajab, NF and Downes, Stephen (1998) Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization Comets for the identification of damaged and repaired DNA sequences in individual cells. MUTAGENESIS, 13 (1). pp. 1-8. [Journal article]

Raleigh, SM, Wanogho, E, Burke, MD, McKeown, Stephanie and Patterson, LH (1998) Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 42 (4). pp. 763-767. [Journal article]


Galligan, ES, Sweetman, SF, McKeown, SR and Strain, JJ (1996) An investigation of the radioprotective action of dietary antioxidants on P388 murine lymphoblastic cells. IRISH JOURNAL OF MEDICAL SCIENCE, 165 (4). pp. 304-305. [Journal article]

Hejmadi, MV, McKeown, SR, Friery, OP, McIntyre, Irene, Patterson, LH and Hirst, DG (1996) DNA damage following combination of radiation with the bioreductive drug AQ4N: Possible selective toxicity to oxic and hypoxic tumour cells. British Journal of Cancer, 73 (4). pp. 499-505. [Journal article]


McKeown, SR, HEJMADI, MV, MCINTYRE, IA, MCALEER, JJA and PATTERSON, LH (1995) Aq4n - an alkylaminoanthraquinone n-oxide showing bioreductive potential and positive interaction with radiation in-vivo. British Journal of Cancer, 72 (1). pp. 76-81. [Journal article]


JOINER, B, HIRST, VK, McKeown, SR, MCALEER, JJA and HIRST, DG (1993) The effect of recombinant-human-erythropoietin treatment on tumor radiosensitivity and cancer-associated anemia in the mouse. British Journal of Cancer, 68 (4). pp. 720-726. [Journal article]


MCALEER, JJA, McKeown, SR, MACMANUS, MP, LAPPIN, TRJ and BRIDGES, JM (1992) Hypobaric hypoxia - a method for testing bioreductive drugs invivo. International Journal of Radiation Oncology Biology Physics, 23 (3). pp. 551-555. [Journal article]


McKeown, SR and ALLEN, IV (1980) Brain temperature after death. Journal of Neuroscience Methods, 2 (1). pp. 103-105. [Journal article]


ALLEN, IV, GLOVER, G, McKeown, SR and MCCORMICK, D (1979) Cellular-origin of lysosomal enzymes in the plaque in multiple-sclerosis .2. Histochemical-study with combined demonstration of myelin and acid-phosphatase. Neuropathology and Applied Neurobiology, 5 (3). pp. 197-210. [Journal article]

McKeown, SR (1979) Postmortem autolytic response in rat-brain lysosomes. Journal of Neurochemistry, 32 (2). pp. 391-396. [Journal article]

McKeown, SR and ALLEN, IV (1979) Fragility of cerebral lysosomes in multiple-sclerosis. Neuropathology and Applied Neurobiology, 5 (5). pp. 405-415. [Journal article]


McKeown, SR (1978) Role of cerebral lysosomes in multiple-sclerosis. IRISH JOURNAL OF MEDICAL SCIENCE, 147 (3). p. 119. [Journal article]

McKeown, SR and ALLEN, IV (1978) Cellular origin of lysosomal enzymes in the plaque in multiple-sclerosis - combined histological and biochemical study. Neuropathology and Applied Neurobiology, 4 (6). pp. 471-482. [Journal article]


McKeown, SR and ALLEN, IV (1977) Lysosomal involvement in pathogenesis of Multiple-Sclerosis. Biochemical Society Transactions, 5 (5). pp. 1416-1418. [Journal article]


Williamson, DH, McKeown, SR and Ilic, V (1975) Metabolic Interactions of Glucose, Acetoacetate and Insulin in Mammary- Glad Slices of Lactating Rats. Biochemical Journal, 150 (2). pp. 145-152. [Journal article]

This list was generated on Sun Sep 15 01:41:11 2019 BST.